Illustration featuring a catheter and an anatomical representation of the human cerebrovascular system.


In recent years, the TNT Lab has published research in a variety of academic journals. Find a featured selection of recent publications below.


Revascularization of a complex case of vertebrobasilar insufficiency with OA-AICA bypass

Madhani SI, Oushy S, Savastano L

World Neurosurg. 2023 Feb 14; 173: 3. doi: 10.1016/j.wneu.2023.02.036. Epub ahead of print.
PubMed Link >

Vagus nerve stimulation using an endovascular electrode array

Nicolai EN, Arturo Larco J, Madhani SI, Asirvatham SJ, Chang SY, Ludwig KA, Savastano LE

bioRxiv. 2023 Feb 24; 2023-02. doi: 10.1101/2023.02.23.529747.
PubMed Link >

Construction and Validation of a Benchtop Model for Testing of Mechanical Thrombectomy Devices for Pulmonary Embolism

Madhani SI, Larco JA, Liu Y, Abbasi M, Shahid AH, Yasin O, Sears V, Morris J, Rosenthal M, Baron S, Savastano L

Cardiovasc Intervent Radiol. 2023 Mar 1; 46 (3): 385-391. doi: 10.1007/s00270-022-03326-5. Epub 2022 Dec 8.
PubMed Link >

A swine model of pulmonary embolism with human-derived thrombi

Arturo Larco JL, Madhani SI, Liu Y, Abbasi M, Shahid AH, Yasin OZ, Moreno C, Vadlamudi V, Savastano LE

Am J Interv Radiol. 2023; 7: 6. doi: 10.25259/AJIR_31_2022.
PubMed Link >

Surgical techniques and nuances for superior cervical ganglionectomy and decentralization in rats

Madhani SI, Klein DC, Muñoz EM, Savastano LE

Methods Mol Biol. 2022 Mar 22; 2550: 53-62. doi: 10.1007/978-1-0716-2593-4_8.
PubMed Link >

Electroencephalogram and heart rate variability features as predictors of responsiveness to vagus nerve stimulation in patients with epilepsy: a systematic review

Madhani SI, Abbasi M, Liu Y, Larco JA, Nicolai E, Worrell G, Savastano L

Childs Nerv Syst. 2022 Nov 1; 38 (11): 2083-2090. doi: 10.1007/s00381-022-05653-x. Epub 2022 Sep 22.
PubMed Link >

Thirty-Day Stroke and Mortality After Carotid Revascularization Among Octogenarians with Symptomatic Carotid Stenosis: Real-World Evidence from a National Surgical Quality Registry

Madhani SI, Alvi MA, Pando A, Alotaibi NM, Lanzino G, Al-Omran M, Savastano L

World Neurosurg. 2022 Nov 1; 167: e40-e52. doi: 10.1016/j.wneu.2022.07.056. Epub 2022 Jul 18.
PubMed Link >

"Near-Clinical" Testing of Neuroendovascular Technology in a" Live" Human Cadaveric Model

Larco JA, Madhani SI, Liu Y, Savastano LE

World Neurosurg. 2022 Oct 1; 166: 225-227. doi: 10.1016/j.wneu.2022.07.051. Epub 2022 Jul 16.
PubMed Link >

Evaluation of an in vivo preclinical model for human middle meningeal artery embolization using the posterior intercostal artery of the swine

Arturo Larco JL, Madhani SI, Liu Y, Abbasi M, Lylyk PN, Benike A, Shahid A, Tekin B, Quinton R, Savastano LE

J Neurointerv Surg. 2022 Aug 23; neurintsurg-2022-019105. doi: 10.1136/jnis-2022-019105.
PubMed Link >

Extra-Intimal Carotid Endarterectomy: Two-Dimensional Microsurgical Approach

Madhani SI, Oushy S, Savastano L

World Neurosurg. 2022 May 1; 161: 169. doi: 10.1016/j.wneu.2022.02.101. Epub 2022 Mar 3.
PubMed Link >

Unifying theory of carotid plaque disruption based on structural phenotypes and forces expressed at the lumen/wall interface

Savastano L, Mousavi H, Liu Y, Khalsa SSS, Zheng Y, Davis E, Reddy A, Brinjikji W, Bhambri A, Cockrum J, Pandey AS, Thompson BG, Gordon D, Seibel EJ, Yonas H

Stroke Vasc Neurol. 2022 Dec 1; 7 (6): 465-475. doi: 10.1136/svn-2021-001451. Epub 2022 Jun 1.
PubMed Link >

Quantification of clot spatial heterogeneity and its impact on thrombectomy

Liu Y, Brinjikji W, Abbasi M, Dai D, Arturo Larco JL, Madhani SI, Shahid AH, Mereuta OM, Nogueira RG, Kvamme P, Layton KF, Delgado Almandoz JE, Hanel RA, Mendes Pereira V, Almekhlafi MA, Yoo AJ, Jahromi BS, Gounis MJ, Patel B, Fitzgerald S, Doyle K, Haussen DC, Al-Bayati AR, Mohammaden M, Pisani L, Rodrigues GM, Thacker IC, Kayan Y, Copelan A, Aghaebrahim A, Sauvageau E, Demchuk AM, Bhuva P, Soomro J, Nazari P, Cantrell DR, Puri AS, Entwistle J, Kadirvel R, Cloft HJ, Kallmes DF, Savastano L.

J Neurointerv Surg. 2022 Dec 1; 14 (12): 1248-1252. doi: 10.1136/neurintsurg-2021-018183. Epub 2021 Dec 15.
PubMed Link >

Preclinical testing platforms for mechanical thrombectomy in stroke: a review on phantoms, in-vivo animal, and cadaveric models

Liu Y, Abbasi M, Arturo Larco JL, Kadirvel R, Kallmes DF, Brinjikji W, Savastano LE

Journal of NeuroInterventional Surgery. 2021; 13 (9): doi: doi:10.1136/neurintsurg-2020-017133.
PubMed Link >

Failure modes and effects analysis of mechanical thrombectomy for stroke discovered in human brains

Liu Y, Gebrezgiabhier D, Reddy A, Davis E, Zheng Y, Arturo Larco JL, Shih AJ, Pandey AS, Savastano LE

Journal of Neurosurgery. 2021; 136 (204): 197-204. doi: 10.3171/2020.11.JNS203684.
PubMed Link >

Analysis of human emboli and thrombectomy forces in large vessel occlusion stroke

Liu Y, Zheng Y, Reddy AS, Gebrezgiabhier D, Davis E, Cockrum J, Gemmete JJ, Chaudhary N, Griauzde JM, Pandey AS, Shih AJ, Savastano LE

Journal of Neurosurgery. 2021 Feb 28; 134 (3): 893-901. doi: 10.3171/2019.12.JNS192187.
PubMed Link >