Publications

In recent years, the TNT Lab has published research in a variety of academic journals. Find a featured selection of recent publications below.

Innovative Testing Platforms

Are orbital branches of the middle meningeal artery underestimated? A human cadaveric angiographic study

Yigit Can Senol, Adrian Liu, Nishanth Krishnan, Prabhat Kumar, Atakan Orscelik, Luis Savastano

Inventional Neuroradiology. 2025 Jul 4; doi: 10.1177/15910199251349658. Epub ahead of print.

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Development and validation of a perfused cadaveric model for neurovascular transradial access with insights from angiography and angioscopy

Yigit Can Senol, Nishanth Krishnan, Mona Asghariahmadabad, Sarosh Irfan Madhani, Adrian Liu, Atakan Orscelik, Raghav Mattay, Woody Han, Matthew Robert Amans, Luis Savastano

Journal of Neurointerventional Surgery. 2025 Jun 12; doi: 10.1136/jnis-2025-023465. Epub ahead of print..

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Vagus nerve stimulation using an endovascular electrode array

Evan N Nicolai, Jorge Arturo Larco, Sarosh I Madhani, Samuel J Asirvatham, Su-Youne Chang, Kip A Ludwig, Luis E Savastano, Gregory A Worrell

bioRxiv. 2023 Feb 24; 2023-02. doi: 10.1101/2023.02.23.529747.

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A swine model of pulmonary embolism with human-derived thrombi

Arturo Larco JL, Madhani SI, Liu Y, Abbasi M, Shahid AH, Yasin OZ, Moreno C, Vadlamudi V, Savastano LE

Am J Interv Radiol. 2023; 7: 6. doi: 10.25259/AJIR_31_2022.

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Surgical techniques and nuances for superior cervical ganglionectomy and decentralization in rats

Sarosh Irfan Madhani, David C Klein, Estela M Muñoz, Luis E Savastano

Methods Mol Biol. 2022 Mar 22; 2550: 53-62. doi: 10.1007/978-1-0716-2593-4_8.

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"Near-Clinical" Testing of Neuroendovascular Technology in a" Live" Human Cadaveric Model

Jorge Arturo Larco, Sarosh Irfan Madhani, Yang Liu, Luis E Savastano

World Neurosurg. 2022 Oct 1; 166: 225-227. doi: 10.1016/j.wneu.2022.07.051. Epub 2022 Jul 16.

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Evaluation of an in vivo preclinical model for human middle meningeal artery embolization using the posterior intercostal artery of the swine

Jorge L Arturo Larco, Sarosh Irfan Madhani, Yang Liu, Mehdi Abbasi, Pedro N Lylyk, Amy Benike, Adnan Shahid, Burak Tekin, Reade Quinton, Luis E Savastano

J Neurointerv Surg. 2022 Aug 23; neurintsurg-2022-019105. doi: 10.1136/jnis-2022-019105.

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Preclinical testing platforms for mechanical thrombectomy in stroke: a review on phantoms, in-vivo animal, and cadaveric models

Yang Liu, Mehdi Abbasi, Jorge L Arturo Larco, Ramanathan Kadirvel, David F Kallmes, Waleed Brinjikji, Luis Savastano

Journal of NeuroInterventional Surgery. 2021; 13 (9): doi: doi:10.1136/neurintsurg-2020-017133.

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Revascularization of a complex case of vertebrobasilar insufficiency with OA-AICA bypass

Sarosh Irfan Madhani, Soliman Oushy, Luis Savastano

World Neurosurgery. 2023 Feb 14; 173: 3. doi: 10.1016/j.wneu.2023.02.036. Epub ahead of print.

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Construction and Validation of a Benchtop Model for Testing of Mechanical Thrombectomy Devices for Pulmonary Embolism

Sarosh Irfan Madhani, Jorge Arturo Larco, Yang Liu, Mehdi Abbasi, Adnan Hussain Shahid, Omar Yasin, Victoria Sears, Jonathan Morris, Mike Rosenthal, Scott Baron, Luis Savastano

Cardiovasc Intervent Radiol. 2023 Mar 1; 46 (3): 385-391. doi: 10.1007/s00270-022-03326-5. Epub 2022 Dec 8.

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Electroencephalogram and heart rate variability features as predictors of responsiveness to vagus nerve stimulation in patients with epilepsy: a systematic review

Sarosh Irfan Madhani, Mehdi Abbasi, Yang Liu, Jorge Arturo Larco, Evan Nicolai, Gregory Worrell, Luis Savastano

Childs Nerv Syst. 2022 Nov 1; 38 (11): 2083-2090. doi: 10.1007/s00381-022-05653-x. Epub 2022 Sep 22.

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Thirty-Day Stroke and Mortality After Carotid Revascularization Among Octogenarians with Symptomatic Carotid Stenosis: Real-World Evidence from a National Surgical Quality Registry

Sarosh Irfan Madhani, Mohammed Ali Alvi, Alejandro Pando, Naif M Alotaibi, Giuseppe Lanzino, Mohammed Al-Omran, Luis Savastano

World Neurosurg. 2022 Nov 1; 167: e40-e52. doi: 10.1016/j.wneu.2022.07.056. Epub 2022 Jul 18.

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Extra-Intimal Carotid Endarterectomy: Two-Dimensional Microsurgical Approach

Sarosh Irfan Madhani, Soliman Oushy, Luis Savastano

World Neurosurg. 2022 May 1; 161: 169. doi: 10.1016/j.wneu.2022.02.101. Epub 2022 Mar 3.

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Deciphering Carotid Plaque Disruption

Unifying theory of carotid plaque disruption based on structural phenotypes and forces expressed at the lumen/wall interface

Luis Savastano, Hossein Mousavi, Yang Liu, Siri Sahib S Khalsa, Yihao Zheng, Evan Davis, Adithya Reddy, Waleed Brinjikji, Ankur Bhambri, Joshua Cockrum, Aditya S Pandey, B Gregory Thompson, David Gordon, Eric J Seibel, Howard Yonas

Stroke Vasc Neurol. 2022 Dec 1; 7 (6): 465-475. doi: 10.1136/svn-2021-001451. Epub 2022 Jun 1.

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The Science of Mechanical Thrombectomy

Quantification of clot spatial heterogeneity and its impact on thrombectomy

Yang Liu, Waleed Brinjikji, Mehdi Abbasi, Daying Dai, Jorge L Arturo Larco, Sarosh Irfan Madhani, Adnan H Shahid, Oana Madalina Mereuta, Raul G Nogueira, Peter Kvamme, Kennith F Layton, Josser E Delgado Almandoz, Ricardo A Hanel, Vitor Mendes Pereira, Mohammed A Almekhlafi, Albert J Yoo, Babak S Jahromi, Matthew J Gounis, Biraj Patel, Seán Fitzgerald, Karen Doyle, Diogo C Haussen, Alhamza R Al-Bayati, Mahmoud Mohammaden, Leonardo Pisani, Gabriel Martins Rodrigues, Ike C Thacker, Yasha Kayan, Alexander Copelan, Amin Aghaebrahim, Eric Sauvageau, Andrew M Demchuk, Parita Bhuva, Jazba Soomro, Pouya Nazari, Donald Robert Cantrell, Ajit S Puri, John Entwistle, Ramanathan Kadirvel, Harry J Cloft, David F Kallmes, Luis Savastano

J Neurointerv Surg. 2022 Dec 1; 14 (12): 1248-1252. doi: 10.1136/neurintsurg-2021-018183. Epub 2021 Dec 15.

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