Publications

In recent years, the TNT Lab has published research in a variety of academic journals. Find a featured selection of recent publications below.

Innovative Testing Platforms

Flat Panel CT 3D rendering and angioscopic correlation of venous stent indentation

Device-anatomy interactions in the dural venous sinuses: angioscopic insights from a perfused human cadaveric model

Yigit Can Senol, Nanditha Krishnan, Adrian Liu, Nishanth Krishnan, Benjamin Cho, Ali Haider, Prabhat Kumar, Panos Pardalidis, Daniel Leong, Matthew Robert Amans, Luis Savastano

Device-anatomy interactions in the dural venous sinuses: angioscopic insights from a perfused human cadaveric model

J Neurointerv Surg. 2026 Jun 12: jnis-2026-025277. doi: 10.1136/jnis-2026-025277. Online ahead of print.

PubMed Link >

Angioscopic evaluation of intraluminal bands with CBCT correlation. (A) Prominent intraluminal septation producing partial compartmentalization of the transverse sinus lumen (B) Elongated fibrous intraluminal band spanning the transverse sinus lumen.(C–E) CBCT multiplanar reconstructions demonstrating a suspected intraluminal band with limited conspicuity on cross-sectional imaging: (C) sagittal, (D) axial, and (E) coronal planes.

Angioscopic study of the major dural venous sinuses in human cadavers

Yigit Can Senol, Adrian Liu, Nishanth Krishnan, Ali Haider, Atakan Orscelik, Prabhat Kumar, Nanditha Krishnan, Benjamin Cho, Panos Pardalidis, Matthew Robert Amans, Luis Savastano

Journal of Neurointerventional Surgery. 2026 Apr 29; Online ahead of print.

PubMed Link >

Are orbital branches of the middle meningeal artery underestimated? A human cadaveric angiographic study

Yigit Can Senol, Adrian Liu, Nishanth Krishnan, Prabhat Kumar, Atakan Orscelik, Luis Savastano

Inventional Neuroradiology. 2025 Jul 4; doi: 10.1177/15910199251349658. Epub ahead of print.

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Development and validation of a perfused cadaveric model for neurovascular transradial access with insights from angiography and angioscopy

Yigit Can Senol, Nishanth Krishnan, Mona Asghariahmadabad, Sarosh Irfan Madhani, Adrian Liu, Atakan Orscelik, Raghav Mattay, Woody Han, Matthew Robert Amans, Luis Savastano

Journal of Neurointerventional Surgery. 2025 Jun 12; doi: 10.1136/jnis-2025-023465. Epub ahead of print..

PubMed Link >

Vagus nerve stimulation using an endovascular electrode array

Evan N Nicolai, Jorge Arturo Larco, Sarosh I Madhani, Samuel J Asirvatham, Su-Youne Chang, Kip A Ludwig, Luis E Savastano, Gregory A Worrell

bioRxiv. 2023 Feb 24; 2023-02. doi: 10.1101/2023.02.23.529747.

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A swine model of pulmonary embolism with human-derived thrombi

Arturo Larco JL, Madhani SI, Liu Y, Abbasi M, Shahid AH, Yasin OZ, Moreno C, Vadlamudi V, Savastano LE

Am J Interv Radiol. 2023; 7: 6. doi: 10.25259/AJIR_31_2022.

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Surgical techniques and nuances for superior cervical ganglionectomy and decentralization in rats

Sarosh Irfan Madhani, David C Klein, Estela M Muñoz, Luis E Savastano

Methods Mol Biol. 2022 Mar 22; 2550: 53-62. doi: 10.1007/978-1-0716-2593-4_8.

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"Near-Clinical" Testing of Neuroendovascular Technology in a" Live" Human Cadaveric Model

Jorge Arturo Larco, Sarosh Irfan Madhani, Yang Liu, Luis E Savastano

World Neurosurg. 2022 Oct 1; 166: 225-227. doi: 10.1016/j.wneu.2022.07.051. Epub 2022 Jul 16.

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Evaluation of an in vivo preclinical model for human middle meningeal artery embolization using the posterior intercostal artery of the swine

Jorge L Arturo Larco, Sarosh Irfan Madhani, Yang Liu, Mehdi Abbasi, Pedro N Lylyk, Amy Benike, Adnan Shahid, Burak Tekin, Reade Quinton, Luis E Savastano

J Neurointerv Surg. 2022 Aug 23; neurintsurg-2022-019105. doi: 10.1136/jnis-2022-019105.

PubMed Link >

Revascularization of a complex case of vertebrobasilar insufficiency with OA-AICA bypass

Sarosh Irfan Madhani, Soliman Oushy, Luis Savastano

World Neurosurgery. 2023 Feb 14; 173: 3. doi: 10.1016/j.wneu.2023.02.036. Epub ahead of print.

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Construction and Validation of a Benchtop Model for Testing of Mechanical Thrombectomy Devices for Pulmonary Embolism

Sarosh Irfan Madhani, Jorge Arturo Larco, Yang Liu, Mehdi Abbasi, Adnan Hussain Shahid, Omar Yasin, Victoria Sears, Jonathan Morris, Mike Rosenthal, Scott Baron, Luis Savastano

Cardiovasc Intervent Radiol. 2023 Mar 1; 46 (3): 385-391. doi: 10.1007/s00270-022-03326-5. Epub 2022 Dec 8.

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Electroencephalogram and heart rate variability features as predictors of responsiveness to vagus nerve stimulation in patients with epilepsy: a systematic review

Sarosh Irfan Madhani, Mehdi Abbasi, Yang Liu, Jorge Arturo Larco, Evan Nicolai, Gregory Worrell, Luis Savastano

Childs Nerv Syst. 2022 Nov 1; 38 (11): 2083-2090. doi: 10.1007/s00381-022-05653-x. Epub 2022 Sep 22.

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Thirty-Day Stroke and Mortality After Carotid Revascularization Among Octogenarians with Symptomatic Carotid Stenosis: Real-World Evidence from a National Surgical Quality Registry

Sarosh Irfan Madhani, Mohammed Ali Alvi, Alejandro Pando, Naif M Alotaibi, Giuseppe Lanzino, Mohammed Al-Omran, Luis Savastano

World Neurosurg. 2022 Nov 1; 167: e40-e52. doi: 10.1016/j.wneu.2022.07.056. Epub 2022 Jul 18.

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Extra-Intimal Carotid Endarterectomy: Two-Dimensional Microsurgical Approach

Sarosh Irfan Madhani, Soliman Oushy, Luis Savastano

World Neurosurg. 2022 May 1; 161: 169. doi: 10.1016/j.wneu.2022.02.101. Epub 2022 Mar 3.

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Deciphering Carotid Plaque Disruption

Unifying theory of carotid plaque disruption based on structural phenotypes and forces expressed at the lumen/wall interface

Luis Savastano, Hossein Mousavi, Yang Liu, Siri Sahib S Khalsa, Yihao Zheng, Evan Davis, Adithya Reddy, Waleed Brinjikji, Ankur Bhambri, Joshua Cockrum, Aditya S Pandey, B Gregory Thompson, David Gordon, Eric J Seibel, Howard Yonas

Stroke Vasc Neurol. 2022 Dec 1; 7 (6): 465-475. doi: 10.1136/svn-2021-001451. Epub 2022 Jun 1.

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